Chlorinated Pyridazin-3-(2H)-ones as Novel Anti-Cancer Agents
نویسندگان
چکیده
منابع مشابه
Efficient 1,3,4-Thiadiazole-4,5-dihydropyridazin-3(2H)-ones as Antimicrobial Agents.
A set of novel series of 1,3,4-thiadiazolyl-sulfanyl-4,5-dihydropyridazin-3(2H)-ones with anticipated antimicrobial activity has been synthesized. The synthetic protocol of the targeted compounds was accomplished by treating β-aroylacrylic acid 1 with 5-amino-1,3,4-thiadiazole-2-thiol (2) to afford the thia-Michael adduct 3. Afterwards, the obtained thia-Michael adduct 3 was cyclized to 4,5-dih...
متن کاملSynthesis of Some Novel 2-substituted-[1,3]thiazolo[3,2-а]benzimidazol-3(2h)-ones as Potent Cytostatic Agents
An optimized method for the synthesis of new 2-substituted-thiazolo[2,3-a]benzimidazole-3(2H)-ones was developed which enabled the target compounds to be obtained in relative good yields through one pot process.Four cancer cell lines: human colorectal cancer cell line HT-29, breast cancer cells MDA-MB-231, cervical cancer cells HeLa, human liver carcinoma cell line HepG2 and human diploid cell ...
متن کامل4-[(tert-Butyldiphenylsilyloxy)methyl]pyridazin-3(2H)-one
In the title compound, C21H24N2O2Si, the carbonyl group of the heterocyclic ring and the O atom of the silyl ether group are placed toward opposite sides and the tert-butyl and pyridazinone moieties are anti-oriented across the Si-O bond [torsion angle = -168.44 (19)°]. In the crystal, mol-ecules are assembled into inversion dimers through co-operative N-H⋯O hydrogen bonds between the NH groups...
متن کاملDiclomezine: 6-(3,5-dichloro-4-methylphenyl)pyridazin-3(2H)-one
In the title compound, C(11)H(8)Cl(2)N(2)O, the benzene and pyridazine rings are tilted by 8.6 (1)° relative to each other. In the crystal, pairs of inter-molecular N-H⋯O hydrogen bonds form centrosymmetric dimers. π-π contacts with centroid-centroid distances of 3.698 (2) and 3.751 (1) Å and halogen-halogen inter-actions [3.379 (1) Å] also stabilize the structure.
متن کاملNovel Oxadiazole Thioglycosides as Potential Anti- Acinetobacter Agents
The glycosylation of 1,3,4-oxadiazole-2-thiones has been performed with peracetylated β-pyranosyl bromide in the presence of potassium carbonate. Deprotection of acetylated thioglycosides was necessary for increasing their antibacterial effects. The structure of nucleosides were confirmed by 1H NMR, 13C NMR and HRMS. The anomeric protons of nucleosides c1–4 were assigned to the doublet, confirm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: SAJ Cancer Science
سال: 2014
ISSN: 2375-6683
DOI: 10.18875/2375-6683.1.102